Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell Senescence

The researches in the dynamic changes of the progress of HSCs aging are very limited and necessary. In this study, male C57BL/6 mice were divided into 5 groups by age. We found that the superoxide damage of HSPCs started to increase from the middle age (6 months old), with notably reduced antioxidat...

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Bibliographic Details
Main Authors: Shan Geng, Xin-Yi Mu, Xiong-Bin Chen, Ji-Ying Hou, Dao-Yong Jia, Chun-Yan Xu, Ya-Ping Wang
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2015/954120