Recruitment of Cbl-b to B cell antigen receptor couples antigen recognition to Toll-like receptor 9 activation in late endosomes.

Recruitment of Cbl-b to B cell antigen receptor couples antigen recognition to Toll-like receptor 9 activation in late endosomes.

Casitas B-lineage lymphoma-b (Cbl-b) is a ubiquitin ligase (E3) that modulates signaling by tagging molecules for degradation. It is a complex protein with multiple domains and binding partners that are not involved in ubiquitinating substrates. Herein, we demonstrate that Cbl-b, but not c-Cbl, is r...

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Bibliographic Details
Main Authors: Margaret Veselits, Azusa Tanaka, Stanley Lipkowitz, Shannon O'Neill, Roger Sciammas, Alison Finnegan, Jian Zhang, Marcus R Clark
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3961229?pdf=render

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http://europepmc.org/articles/PMC3961229?pdf=render

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