TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

<p>Abstract</p> <p>The role of tumor necrosis factor (TNF) as an immune mediator has long been appreciated but its function in the brain is still unclear. TNF receptor 1 (TNFR1) is expressed in most cell types, and can be activated by binding of either soluble TNF (solTNF) or trans...

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Bibliographic Details
Main Authors: Tansey Malú G, McCoy Melissa K
Format: Article
Language:English
Published: BMC 2008-10-01
Series:Journal of Neuroinflammation
Online Access:http://www.jneuroinflammation.com/content/5/1/45