Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.

Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection.

The role of sirtuin-1 (SIRT1) in innate immunity, and in particular the influence of SIRT1 on antimicrobial defense against infection, has yet to be reported but is important to define since SIRT1 inhibitors are being investigated as therapeutic agents in the treatment of cancer, Huntington's d...

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Bibliographic Details
Main Authors: Laura E Crotty Alexander, Brenda J Marsh, Anjuli M Timmer, Ann E Lin, Kayvan Zainabadi, Agnieszka Czopik, Leonard Guarente, Victor Nizet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3873454?pdf=render

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http://europepmc.org/articles/PMC3873454?pdf=render

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