Investigating receptor-mediated antibody transcytosis using blood–brain barrier organoid arrays

Investigating receptor-mediated antibody transcytosis using blood–brain barrier organoid arrays

Abstract Background The pathways that control protein transport across the blood–brain barrier (BBB) remain poorly characterized. Despite great advances in recapitulating the human BBB in vitro, current models are not suitable for systematic analysis of the molecular mechanisms of antibody transport...

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Bibliographic Details
Main Authors: Claire Simonneau, Martina Duschmalé, Alina Gavrilov, Nathalie Brandenberg, Sylke Hoehnel, Camilla Ceroni, Evodie Lassalle, Elena Kassianidou, Hendrik Knoetgen, Jens Niewoehner, Roberto Villaseñor
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood–brain barrier
Organoids
Receptor-mediated transcytosis
High-throughput in vitro model
Online Access:https://doi.org/10.1186/s12987-021-00276-x

Internet

https://doi.org/10.1186/s12987-021-00276-x

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