Advances and perspectives of PARP inhibitors

Advances and perspectives of PARP inhibitors

Abstract DNA damage repair deficiency leads to the increased risk of genome instability and oncogenic transformation. In the meanwhile, this deficiency could be exploited for cancer treatment by inducing excessive genome instability and catastrophic DNA damage. Continuous DNA replication in cancer c...

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Bibliographic Details
Main Authors: Ming Yi, Bing Dong, Shuang Qin, Qian Chu, Kongming Wu, Suxia Luo
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Experimental Hematology & Oncology
Subjects:
PARPi
DNA repair
Synthetic lethal
Combination therapy
Immune checkpoint inhibitor
Online Access:http://link.springer.com/article/10.1186/s40164-019-0154-9

Internet

http://link.springer.com/article/10.1186/s40164-019-0154-9

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