Cascade alkylarylation of substituted N-allylbenzamides for the construction of dihydroisoquinolin-1(2H)-ones and isoquinoline-1,3(2H,4H)-diones

Cascade alkylarylation of substituted N-allylbenzamides for the construction of dihydroisoquinolin-1(2H)-ones and isoquinoline-1,3(2H,4H)-diones

An oxidative reaction for the synthesis of 4-alkyl-substituted dihydroisoquinolin-1(2H)-ones with N-allylbenzamide derivatives as starting materials has been developed. The radical alkylarylation reaction proceeds through a sequence of alkylation and intramolecular cyclization. The substituent on th...

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Bibliographic Details
Main Authors: Ping Qian, Bingnan Du, Wei Jiao, Haibo Mei, Jianlin Han, Yi Pan
Format: Article
Language:English
Published: Beilstein-Institut 2016-02-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
C(sp3)–H bond functionalization
cyclization
dihydroisoquinolin-1(2H)-one
N-allylbenzamides
oxidation
Online Access:https://doi.org/10.3762/bjoc.12.32

Internet

https://doi.org/10.3762/bjoc.12.32

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