The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer

The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer

Summary: We identified a regulatory system that acts downstream of Wnt/β-catenin signaling in salivary gland and head and neck carcinomas. We show in a mouse tumor model of K14-Cre-induced Wnt/β-catenin gain-of-function and Bmpr1a loss-of-function mutations that tumor-propagating cells exhibit incre...

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Bibliographic Details
Main Authors: Qionghua Zhu, Liang Fang, Julian Heuberger, Andrea Kranz, Jörg Schipper, Kathrin Scheckenbach, Ramon Oliveira Vidal, Daniele Yumi Sunaga-Franze, Marion Müller, Annika Wulf-Goldenberg, Sascha Sauer, Walter Birchmeier
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718320047

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