Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway

Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway

Familial hypercholesterolemia is a genetic disorder that results from various gene mutations, primarily within the LDL receptor (LDLR). Approximately 50% of the LDLR mutations are defined as class 2 mutations, with the mutant proteins partially or entirely retained in the endoplasmic reticulum. To d...

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Bibliographic Details
Main Authors: Yonghe Li, Wenyan Lu, Alan L. Schwartz, Guojun Bu
Format: Article
Language:English
Published: Elsevier 2004-06-01
Series:Journal of Lipid Research
Subjects:
familial hypercholesterolemia
mutation
degradation
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752031806X

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http://www.sciencedirect.com/science/article/pii/S002222752031806X

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