ATF4-Dependent <i>NRF2</i> Transcriptional Regulation Promotes Antioxidant Protection during Endoplasmic Reticulum Stress

ATF4-Dependent <i>NRF2</i> Transcriptional Regulation Promotes Antioxidant Protection during Endoplasmic Reticulum Stress

Endoplasmic reticulum (ER) stress generates reactive oxygen species (ROS) that induce apoptosis if left unabated. To limit oxidative insults, the ER stress PKR-like endoplasmic reticulum Kinase (PERK) has been reported to phosphorylate and activate nuclear factor erythroid 2-related factor 2 (NRF2)....

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Bibliographic Details
Main Authors: Carmen Sarcinelli, Helena Dragic, Marie Piecyk, Virginie Barbet, Cédric Duret, Audrey Barthelaix, Carole Ferraro-Peyret, Joelle Fauvre, Toufic Renno, Cédric Chaveroux, Serge N. Manié
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
nrf2
ros
er stress
perk
atf4
Online Access:https://www.mdpi.com/2072-6694/12/3/569

Internet

https://www.mdpi.com/2072-6694/12/3/569

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