Strain- and sex-dependent circadian changes in abcc2 transporter expression: implications for irinotecan chronotolerance in mouse ileum.

Strain- and sex-dependent circadian changes in abcc2 transporter expression: implications for irinotecan chronotolerance in mouse ileum.

ATP-binding cassette transporter abcc2 is involved in the cellular efflux of irinotecan. The drug is toxic for mouse ileum, where abcc2 is highly expressed. Here, we investigate whether circadian changes in local abcc2 expression participate in the circadian rhythm of irinotecan toxicity for ileum m...

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Bibliographic Details
Main Authors: Alper Okyar, Enza Piccolo, Constance Ahowesso, Elisabeth Filipski, Virginie Hossard, Catherine Guettier, Rosanna La Sorda, Nicola Tinari, Stefano Iacobelli, Francis Lévi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3108586?pdf=render

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http://europepmc.org/articles/PMC3108586?pdf=render

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