Design, Synthesis, and Evaluation of Novel 3-Carboranyl-1,8-Naphthalimide Derivatives as Potential Anticancer Agents

Design, Synthesis, and Evaluation of Novel 3-Carboranyl-1,8-Naphthalimide Derivatives as Potential Anticancer Agents

We synthesized a series of novel 3-carboranyl-1,8-naphthalimide derivatives, mitonafide and pinafide analogs, using click chemistry, reductive amination and amidation reactions and investigated their in vitro effects on cytotoxicity, cell death, cell cycle, and the production of reactive oxygen spec...

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Bibliographic Details
Main Authors: Sebastian Rykowski, Dorota Gurda-Woźna, Marta Orlicka-Płocka, Agnieszka Fedoruk-Wyszomirska, Małgorzata Giel-Pietraszuk, Eliza Wyszko, Aleksandra Kowalczyk, Paweł Stączek, Andrzej Bak, Agnieszka Kiliszek, Wojciech Rypniewski, Agnieszka B. Olejniczak
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
naphthalimides
carborane
anticancer activity
Online Access:https://www.mdpi.com/1422-0067/22/5/2772

Internet

https://www.mdpi.com/1422-0067/22/5/2772

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