Distinct subtypes of genomic PTEN deletion size influence the landscape of aneuploidy and outcome in prostate cancer

Distinct subtypes of genomic PTEN deletion size influence the landscape of aneuploidy and outcome in prostate cancer

Abstract Background Inactivation of the PTEN tumor suppressor gene by deletion occurs in 20–30% of prostate cancer tumors and loss strongly correlates with a worse outcome. PTEN loss of function not only leads to activation of the PI3K/AKT pathway, but is also thought to affect genome stability and...

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Bibliographic Details
Main Authors: Thiago Vidotto, Daniel Guimarães Tiezzi, Jeremy A. Squire
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Molecular Cytogenetics
Subjects:
TCGA
Prostate cancer
Genomic instability
PTEN
Chromosome 10
Online Access:http://link.springer.com/article/10.1186/s13039-017-0348-y

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http://link.springer.com/article/10.1186/s13039-017-0348-y

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