A binding-site barrier affects imaging efficiency of high affinity amyloid-reactive peptide radiotracers in vivo.

Amyloid is a complex pathology associated with a growing number of diseases including Alzheimer's disease, type 2 diabetes, rheumatoid arthritis, and myeloma. The distribution and extent of amyloid deposition in body organs establishes the prognosis and can define treatment options; therefore,...

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Bibliographic Details
Main Authors: Jonathan S Wall, Angela Williams, Tina Richey, Alan Stuckey, Ying Huang, Craig Wooliver, Sallie Macy, Eric Heidel, Neil Gupta, Angela Lee, Brianna Rader, Emily B Martin, Stephen J Kennel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3672142?pdf=render