Intrauterine exposure to chronic hypoxia in the rat leads to progressive diastolic function and increased aortic stiffness from early postnatal developmental stages

Intrauterine exposure to chronic hypoxia in the rat leads to progressive diastolic function and increased aortic stiffness from early postnatal developmental stages

Abstract Aim We sought to explore whether fetal hypoxia exposure, an insult of placental insufficiency, is associated with left ventricular dysfunction and increased aortic stiffness at early postnatal ages. Methods Pregnant Sprague Dawley rats were exposed to hypoxic conditions (11.5% FiO2) from em...

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Bibliographic Details
Main Authors: Praveen Kumar, Jude S. Morton, Amin Shah, Victor Do, Consolato Sergi, Jesus Serrano‐Lomelin, Sandra T. Davidge, Donna Beker, Jody Levasseur, Lisa K. Hornberger
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Physiological Reports
Subjects:
cardiovascular programming
development
diastolic dysfunction
echocardiography
intrauterine growth restriction (IUGR)
myocardial function
Online Access:https://doi.org/10.14814/phy2.14327

Internet

https://doi.org/10.14814/phy2.14327

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