Molecular features of interaction between VEGFA and anti-angiogenic drugs used in retinal diseases: a computational approach

Molecular features of interaction between VEGFA and anti-angiogenic drugs used in retinal diseases: a computational approach

Anti-angiogenic agents are biological drugs used for treatment of retinal neovascular degenerative diseases. In this study, we aimed at in-silico analysis of interaction of vascular endothelial growth factor A (VEGFA), the main mediator of angiogenesis, with binding domains of anti-angiogenic agents...

Full description

Bibliographic Details
Main Authors: Chiara Bianca Maria Platania, Luisa eDi Paola, Gian Marco eLeggio, Giovanni Luca eRomano, Filippo eDrago, Salvatore eSalomone, Claudio eBucolo
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Pharmacology
Subjects:
Diabetic Retinopathy
molecular dynamics
bevacizumab
Aflibercept
Ranibizumab
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00248/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00248/full

Similar Items