A Genome-Wide CRISPR/Cas9 Screen Reveals that Riboflavin Regulates Hydrogen Peroxide Entry into HAP1 Cells

A Genome-Wide CRISPR/Cas9 Screen Reveals that Riboflavin Regulates Hydrogen Peroxide Entry into HAP1 Cells

Using a genetic screen, we discovered that riboflavin controls the entry of hydrogen peroxide into a white blood cell line. To our knowledge, this is the first report of a vitamin playing a role in controlling transport of a small molecule across the cell membrane.Extracellular hydrogen peroxide can...

Full description

Bibliographic Details
Main Authors: Tamutenda Chidawanyika, Kenneth M. K. Mark, Surachai Supattapone
Format: Article
Language:English
Published: American Society for Microbiology 2020-08-01
Series:mBio
Subjects:
riboflavin
oxidative stress
hydrogen peroxide
aquaporin
keap1
riboflavin transporter
retinol saturase
p450 oxidoreductase
membrane transport
Online Access:https://doi.org/10.1128/mBio.01704-20

Internet

https://doi.org/10.1128/mBio.01704-20

Similar Items