Clozapine Normalizes a Glutamatergic Transmission Abnormality Induced by an Impaired NMDA Receptor in the Thalamocortical Pathway via the Activation of a Group III Metabotropic Glutamate Receptor

Clozapine Normalizes a Glutamatergic Transmission Abnormality Induced by an Impaired NMDA Receptor in the Thalamocortical Pathway via the Activation of a Group III Metabotropic Glutamate Receptor

Pharmacological mechanisms of gold-standard antipsychotics against treatment-refractory schizophrenia, such as clozapine (CLZ), remain unclear. We aimed to explore the mechanisms of CLZ by investigating the effects of MK801 and CLZ on tripartite synaptic transmission in the thalamocortical glutamate...

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Bibliographic Details
Main Authors: Kouji Fukuyama, Ryo Kato, Masahiko Murata, Takashi Shiroyama, Motohiro Okada
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Biomolecules
Subjects:
clozapine
schizophrenia
NMDA/glutamate receptor
metabotropic glutamate receptor
thalamocortical pathway
Online Access:https://www.mdpi.com/2218-273X/9/6/234

Internet

https://www.mdpi.com/2218-273X/9/6/234

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