Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair

Mammalian Tyrosyl-DNA Phosphodiesterases in the Context of Mitochondrial DNA Repair

Mammalian mitochondria contain four topoisomerases encoded in the nuclear genome: TOP1MT, TOP2&#945;, TOP2&#946;, and TOP3&#945;. They also contain the two known tyrosyl-DNA phosphodiesterases (TDPs): TDP1 and TDP2, including a specific TDP2<sup>S</sup> isoform. Both TDP1 and...

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Bibliographic Details
Main Authors: Shar-yin Naomi Huang, Yves Pommier
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondrial DNA
topoisomerases
TDP1
TDP2
ROS
SCAN1
neurological disorders
cancer
antibiotics and antiviral agents
Online Access:https://www.mdpi.com/1422-0067/20/12/3015

Internet

https://www.mdpi.com/1422-0067/20/12/3015

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