Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human

Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human

Abstract Receptor-mediated transcytosis (RMT) is a principal pathway for transport of macromolecules essential for brain function across the blood–brain barrier (BBB). Antibodies or peptide ligands which bind RMT receptors are often co-opted for brain delivery of biotherapeutics. Constitutively recy...

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Bibliographic Details
Main Authors: Wandong Zhang, Qing Yan Liu, Arsalan S. Haqqani, Sonia Leclerc, Ziying Liu, François Fauteux, Ewa Baumann, Christie E. Delaney, Dao Ly, Alexandra T. Star, Eric Brunette, Caroline Sodja, Melissa Hewitt, Jagdeep K. Sandhu, Danica B. Stanimirovic
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Fluids and Barriers of the CNS
Subjects:
Blood–brain barrier
Receptor-mediated transcytosis
Isolated brain microvessels
RNAseq
Mouse and human species
IGF1R
Online Access:http://link.springer.com/article/10.1186/s12987-020-00209-0

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http://link.springer.com/article/10.1186/s12987-020-00209-0

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