Levosimendan increases brain tissue oxygen levels after cardiopulmonary resuscitation independent of cardiac function and cerebral perfusion

Abstract Prompt reperfusion is important to rescue ischemic tissue; however, the process itself presents a key pathomechanism that contributes to a poor outcome following cardiac arrest. Experimental data have suggested the use of levosimendan to limit ischemia–reperfusion injury by improving cerebr...

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Bibliographic Details
Main Authors: Andreas García-Bardon, Jens Kamuf, Alexander Ziebart, Tanghua Liu, Nadia Krebs, Bastian Dünges, Robert F. Kelm, Svenja Morsbach, Kristin Mohr, Axel Heimann, Erik K. Hartmann, Serge C. Thal
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-93621-x