Silencing of the HER2/neu Gene by siRNA Inhibits Proliferation and Induces Apoptosis in HER2/neu-Overexpressing Breast Cancer Cells

Silencing of the HER2/neu Gene by siRNA Inhibits Proliferation and Induces Apoptosis in HER2/neu-Overexpressing Breast Cancer Cells

In eukaryotes, double-stranded (ds) RNA induces sequence-specific inhibition of gene expression referred to as RNA interference (RNAi). We exploited RNAi to define the role of HER2/neu in the neoplastic proliferation of human breast cancer cells. We transfected SK-BR-3, BT-474, MCF-7, and MDA-MB-46...

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Bibliographic Details
Main Authors: Timo Faltus, Juping Yuan, Brigitte Zimmer, Andrea Kramer, Sibylle Loibl, Manfred Kaufmann, Klaus Strebhardt
Format: Article
Language:English
Published: Elsevier 2004-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
HER2/neu
RNA interference
siRNA
antiproliferative activity
apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558604800113

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http://www.sciencedirect.com/science/article/pii/S1476558604800113

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