Cosmosiin Increases ADAM10 Expression via Mechanisms Involving 5’UTR and PI3K Signaling

Cosmosiin Increases ADAM10 Expression via Mechanisms Involving 5’UTR and PI3K Signaling

The α-secretase “a disintegrin and metalloproteinase domain-containing protein” (ADAM10) is involved in the processing of amyloid precursor protein (APP). Upregulation of ADAM10 precludes the generation of neurotoxic β-amyloid protein (Aβ) and represents a plausible therapeutic strategy for Alzheime...

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Bibliographic Details
Main Authors: Zhuo Min, Ying Tang, Xiao-Tong Hu, Bing-Lin Zhu, Yuan-Lin Ma, Jing-Si Zha, Xiao-Juan Deng, Zhen Yan, Guo-Jun Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cosmosiin
ADAM10
translation
5’UTR
PI3K
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00198/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00198/full

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