5-Arylidene(chromenyl-methylene)-thiazolidinediones: Potential New Agents against Mutant Oncoproteins K-Ras, N-Ras and B-Raf in Colorectal Cancer and Melanoma

5-Arylidene(chromenyl-methylene)-thiazolidinediones: Potential New Agents against Mutant Oncoproteins K-Ras, N-Ras and B-Raf in Colorectal Cancer and Melanoma

<i>Background and objectives:</i> Cancer represents the miscommunication between and within the body cells. The mutations of the oncogenes encoding the MAPK pathways play an important role in the development of tumoral diseases. The mutations of KRAS and BRAF oncogenes are involved in co...

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Bibliographic Details
Main Authors: Cristina Nastasă, Radu Tamaian, Ovidiu Oniga, Brîndușa Tiperciuc
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Medicina
Subjects:
thiazolidine-2,4-dione
K-Ras
N-Ras
B-Raf
cytotoxicity
ADME-Tox
molecular docking
Online Access:https://www.mdpi.com/1010-660X/55/4/85

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https://www.mdpi.com/1010-660X/55/4/85

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