HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions

HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions

The vitamin D receptor/retinoid X receptor-α heterodimer (VDRRXRα) regulates bone mineralization. Here the authors employ hydrogen/deuterium exchange (HDX) mass spectrometry to study the conformational dynamics of VDRRXRα and give mechanistic insights into how VDRRXRα controls the transcriptional ac...

Full description

Bibliographic Details
Main Authors: Jie Zheng, Mi Ra Chang, Ryan E. Stites, Yong Wang, John B. Bruning, Bruce D. Pascal, Scott J. Novick, Ruben D. Garcia-Ordonez, Keith R. Stayrook, Michael J. Chalmers, Jeffrey A. Dodge, Patrick R. Griffin
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00978-7

Internet

https://doi.org/10.1038/s41467-017-00978-7

Similar Items