Syntheses, Crystal Structures, and Antitumor Activities of Copper(II) and Nickel(II) Complexes with 2-((2-(Pyridin-2-yl)hydrazono)methyl)quinolin-8-ol

Syntheses, Crystal Structures, and Antitumor Activities of Copper(II) and Nickel(II) Complexes with 2-((2-(Pyridin-2-yl)hydrazono)methyl)quinolin-8-ol

Two transition metal complexes with 2-((2-(pyridin-2-yl)hydrazono)methyl)quinolin-8-ol (L), [Cu(L)Cl2]2 (1) and [Ni(L)Cl2]·CH2Cl2 (2), were synthesized and fully characterized. Complex 1 exhibited high in vitro antitumor activity against SK-OV-3, MGC80-3 and HeLa cells with IC50 values of...

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Bibliographic Details
Main Authors: Qi-Yuan Yang, Qian-Qian Cao, Qi-Pin Qin, Cai-Xing Deng, Hong Liang, Zhen-Feng Chen
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:International Journal of Molecular Sciences
Subjects:
quinolinyl hydrazine
copper(II) complex
cytotoxicity
apoptosis
Online Access:http://www.mdpi.com/1422-0067/19/7/1874

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http://www.mdpi.com/1422-0067/19/7/1874

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