Potential prophylactic effect of chemical chaperones for alleviation of endoplasmic reticulum stress in experimental diabetic cataract

Potential prophylactic effect of chemical chaperones for alleviation of endoplasmic reticulum stress in experimental diabetic cataract

Abstract Background Imbalance between protein synthesis and endoplasmic reticulum (ER) capacity to modify and fold proteins lead to the accumulation of unfolded proteins resulting in ER stress and apoptosis. Chaperones are major defense molecules assisting in protein folding, transport, and cellular...

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Main Authors: Amany Abdel-Ghaffar, Ghada G. Elhossary, Atef M. Mahmoud, Amany H. M. Elshazly, Olfat A. Hassanin, Anisa Saleh, Sahar M. Mansour, Fatma G. Metwally, Laila K. Hanafy, Sawsan H. Karam, Hager E. Amer, Nadia A. Samy, Ahmed Mostafa Ata
Format: Article
Language:English
Published: SpringerOpen 2019-04-01
Series:Bulletin of the National Research Centre
Subjects:
ER stress
Diabetes mellitus
Cataract
Chaperones
TUDCA
4-PBA
Online Access:http://link.springer.com/article/10.1186/s42269-019-0089-7

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http://link.springer.com/article/10.1186/s42269-019-0089-7

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