Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea

Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea

Abstract Background Recently, increased tumor incidence and cancer-related mortality have been reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to the metastasis of tumors. However, the molecular mechanisms by which tumor...

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Bibliographic Details
Main Authors: Lian Li, Fangyuan Ren, Chao Qi, Leiqian Xu, Yinshan Fang, Maoli Liang, Jing Feng, Baoyuan Chen, Wen Ning, Jie Cao
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Respiratory Research
Subjects:
Obstructive sleep apnea
Intermittent hypoxia
Lung metastasis
Oxidative stress
Inflammation
Antioxidant tempol
Online Access:http://link.springer.com/article/10.1186/s12931-018-0727-x

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http://link.springer.com/article/10.1186/s12931-018-0727-x

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