Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents: an in vitro study.

Adenosine acting in the basal forebrain is a key mediator of sleep homeostasis. Extracellular adenosine concentrations increase during wakefulness, especially during prolonged wakefulness and lead to increased sleep pressure and subsequent rebound sleep. The release of endogenous adenosine during th...

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Bibliographic Details
Main Authors: Robert Edward Sims, Houdini Ho Tin Wu, Nicholas Dale
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3543262?pdf=render