Combination of multicomponent KA2 and Pauson–Khand reactions: short synthesis of spirocyclic pyrrolocyclopentenones

Combination of multicomponent KA2 and Pauson–Khand reactions: short synthesis of spirocyclic pyrrolocyclopentenones

The Cu-catalyzed multicomponent ketone–amine–alkyne (KA2) reaction was combined with a Pauson–Khand cycloaddition to give access of unprecedented constrained spirocyclic pyrrolocyclopentenone derivatives following a DOS couple-pair approach. The polyfunctional molecular scaffolds were tested on the...

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Bibliographic Details
Main Authors: Riccardo Innocenti, Elena Lenci, Gloria Menchi, Andrea Trabocchi
Format: Article
Language:English
Published: Beilstein-Institut 2020-02-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
chemical libraries
chemoinformatics
cu-catalysis
cycloadditions
molecular scaffolds
multicomponent reactions
Online Access:https://doi.org/10.3762/bjoc.16.23

Internet

https://doi.org/10.3762/bjoc.16.23

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