Oncogenic role of dysregulated leptin signaling in the pathogenesis of ovarian cancer

Oncogenic role of dysregulated leptin signaling in the pathogenesis of ovarian cancer

Abstract Leptin, a pleiotropic hormone is produced by adipose tissues and plays a critical role in various biological functions. Leptin mediates its function through interaction with specific receptors. The leptin-receptor interaction modulates activation of a number of signaling pathways, such as J...

Full description

Bibliographic Details
Main Authors: Iman W. Achkar, Ajaz A. Bhat, Maria Zafar, Madiha Abbas, Omar S. Khan, Shilpa Kuttikrishnan, Kirti S. Prabhu, Shahab Uddin
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Translational Medicine Communications
Subjects:
Leptin
Ob-R
PI3K/AKT pathway
Ovarian Cancer
Online Access:http://link.springer.com/article/10.1186/s41231-018-0031-2
Description
Summary:Abstract Leptin, a pleiotropic hormone is produced by adipose tissues and plays a critical role in various biological functions. Leptin mediates its function through interaction with specific receptors. The leptin-receptor interaction modulates activation of a number of signaling pathways, such as JAK-STAT, PI3-Kinase-AKT and MAP kinases. Recently, deregulated leptin-mediated signaling has been shown in many cancers including ovarian cancer. A number of studies have shown a link between obesity and carcinogenesis of different cancers via leptin deregulated signaling pathways. In this review, we highlighted the role of deregulated leptin receptor-mediated signaling in the etiology of ovarian cancer.
ISSN:2396-832X

Similar Items