Histone Deacetylase 5 Is an Early Epigenetic Regulator of Intermittent Hypoxia Induced Sympathetic Nerve Activation and Blood Pressure

Histone Deacetylase 5 Is an Early Epigenetic Regulator of Intermittent Hypoxia Induced Sympathetic Nerve Activation and Blood Pressure

Intermittent hypoxia (IH) is a hallmark manifestation of obstructive sleep apnea (OSA). Long term IH (LT-IH) triggers epigenetic reprogramming of the redox state involving DNA hypermethylation in the carotid body chemo reflex pathway resulting in persistent sympathetic activation and hypertension. P...

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Bibliographic Details
Main Authors: Ning Wang, Ying-Jie Peng, Xiaoyu Su, Nanduri R. Prabhakar, Jayasri Nanduri
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Physiology
Subjects:
intermittent hypoxia
obstructive sleep apnea
lysine deacetylase
HDAC5
histone 3
HIF-1
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.688322/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.688322/full

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