Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis

Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis

Proopiomelanocortin (POMC) neurons are major negative regulators of energy balance. A distinct developmental property of POMC neurons is that they can adopt an orexigenic neuropeptide Y (NPY) phenotype. However, the mechanisms underlying the differentiation of Pomc progenitors remain unknown. Here,...

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Bibliographic Details
Main Authors: Sophie Croizier, Soyoung Park, Julien Maillard, Sebastien G Bouret
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-10-01
Series:eLife
Subjects:
hypothalamus
obesity
glucose homeostasis
development
Proopiomelanocortin
miRNA
Online Access:https://elifesciences.org/articles/40429

Internet

https://elifesciences.org/articles/40429

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