Targeting Chronic Myeloid Leukemia Stem/Progenitor Cells Using Venetoclax-Loaded Immunoliposome

Targeting Chronic Myeloid Leukemia Stem/Progenitor Cells Using Venetoclax-Loaded Immunoliposome

CML is a hematopoietic stem-cell disorder emanating from breakpoint cluster region/Abelson murine leukemia 1 (BCR/ABL) translocation. Introduction of different TKIs revolutionized treatment outcome in CML patients, but CML LSCs seem insensitive to TKIs and are detectable in newly diagnosed and resis...

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Bibliographic Details
Main Authors: Mohammad Houshmand, Francesca Garello, Rachele Stefania, Valentina Gaidano, Alessandro Cignetti, Michela Spinelli, Carmen Fava, Mahin Nikougoftar Zarif, Sara Galimberti, Ester Pungolino, Mario Annunziata, Luigia Luciano, Giorgina Specchia, Monica Bocchia, Gianni Binotto, Massimiliano Bonifacio, Bruno Martino, Patrizia Pregno, Fabio Stagno, Alessandra Iurlo, Sabina Russo, Silvio Aime, Paola Circosta, Giuseppe Saglio
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
chronic myeloid leukemia
leukemia stem cell
CD26
liposome
immunoliposome
targeted therapy
Online Access:https://www.mdpi.com/2072-6694/13/6/1311

Internet

https://www.mdpi.com/2072-6694/13/6/1311

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