Antivirulence DsbA inhibitors attenuate Salmonella enterica serovar Typhimurium fitness without detectable resistance

Antivirulence DsbA inhibitors attenuate Salmonella enterica serovar Typhimurium fitness without detectable resistance

ABSTRACT Inhibition of the DiSulfide Bond (DSB) oxidative protein folding machinery, a major facilitator of virulence in Gram‐negative bacteria, represents a promising antivirulence strategy. We previously developed small molecule inhibitors of DsbA from Escherichia coli K‐12 (EcDsbA) and showed tha...

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Bibliographic Details
Main Authors: Rabeb Dhouib, Dimitrios Vagenas, Yaoqin Hong, Anthony D. Verderosa, Jennifer L Martin, Begoña Heras, Makrina Totsika
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:FASEB BioAdvances
Subjects:
antimicrobial resistance
disulfide bond
enzyme inhibitors
experimental evolution
infection
Online Access:https://doi.org/10.1096/fba.2020-00100

Internet

https://doi.org/10.1096/fba.2020-00100

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