Eplerenone Reverses Cardiac Fibrosis via the Suppression of Tregs by Inhibition of Kv1.3 Channel

Eplerenone Reverses Cardiac Fibrosis via the Suppression of Tregs by Inhibition of Kv1.3 Channel

Background: Fibroblast proliferation is a critical feature during heart failure development. Previous studies reported regulatory T-lymphocytes (Tregs)’ protective role against myocardial fibrosis. However, notably, Tregs also secrete fibrogenic cytokine TGF-β when activated. This study aimed to cla...

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Bibliographic Details
Main Authors: Pei-Pei Shao, Chang-Jiang Liu, Qi Xu, Bo Zhang, Shao-Hua Li, Yang Wu, Zhan Sun, Lu-Feng Cheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Physiology
Subjects:
eplerenone
cardiac fibrosis
CD4+CD25+ Treg lymphocytes
Kv1.3 channel
TGF-β
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00899/full

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https://www.frontiersin.org/article/10.3389/fphys.2018.00899/full

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