Antigen Production After Latency Reversal and Expression of Inhibitory Receptors in CD8+ T Cells Limit the Killing of HIV-1 Reactivated Cells

Antigen Production After Latency Reversal and Expression of Inhibitory Receptors in CD8+ T Cells Limit the Killing of HIV-1 Reactivated Cells

The so-called shock and kill therapies aim to combine HIV-1 reactivation by latency-reversing agents (LRA) with immune clearance to purge the HIV-1 reservoir. The clinical use of LRA has demonstrated detectable perturbations in the HIV-1 reservoir without measurable reductions to date. Consequently,...

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Bibliographic Details
Main Authors: Alba Ruiz, Oscar Blanch-Lombarte, Esther Jimenez-Moyano, Dan Ouchi, Beatriz Mothe, Ruth Peña, Cristina Galvez, Meritxell Genescà, Javier Martinez-Picado, Philip Goulder, Richard Barnard, Bonnie Howell, Bonaventura Clotet, Julia G. Prado
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
human immunodeficiency virus
HIV-1 reservoir
HIV-1 immunogen
shock and kill
CTL (Cytotoxic T lymphocyte)
inhibitory receptors
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03162/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.03162/full

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