Diphenyleneiodonium, an inhibitor of NOXes and DUOXes, is also an iodide-specific transporter

Diphenyleneiodonium, an inhibitor of NOXes and DUOXes, is also an iodide-specific transporter

NADPH oxidases (NOXes) and dual oxidases (DUOXes) generate O2.− and H2O2. Diphenyleneiodonium (DPI) inhibits the activity of these enzymes and is often used as a specific inhibitor. It is shown here that DPI, at concentrations similar to those which inhibit the generation of O2 derivatives, activate...

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Bibliographic Details
Main Authors: C. Massart, N. Giusti, R. Beauwens, J.E. Dumont, F. Miot, J. Van Sande
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
Diphenyleneiodonium
O2 radical generation
NOX
DUOX
Iodide efflux
Thyroid
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546313000740

Internet

http://www.sciencedirect.com/science/article/pii/S2211546313000740

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