An analysis of the cross-reactivity of autoantibodies to GAD65 and GAD67 in diabetes.

BACKGROUND: Autoantibodies to GAD65 (anti-GAD65) are present in the sera of 70-80% of patients with type 1 diabetes (T1D), but antibodies to the structurally similar 67 kDa isoform GAD67 are rare. Antibodies to GAD67 may represent a cross-reactive population of anti-GAD65, but this has not been form...

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Bibliographic Details
Main Authors: Bindu Jayakrishnan, David E Hoke, Christopher G Langendorf, Ashley M Buckle, Merrill J Rowley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3072979?pdf=render