Geospatial Cellular Distribution of Cancer-Associated Fibroblasts Significantly Impacts Clinical Outcomes in Metastatic Clear Cell Renal Cell Carcinoma

Geospatial Cellular Distribution of Cancer-Associated Fibroblasts Significantly Impacts Clinical Outcomes in Metastatic Clear Cell Renal Cell Carcinoma

Cancer-associated fibroblasts (CAF) are highly prevalent cells in the tumor microenvironment in clear cell renal cell carcinoma (ccRCC). CAFs exhibit a pro-tumor effect in vitro and have been implicated in tumor cell proliferation, metastasis, and treatment resistance. Our objective is to analyze th...

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Bibliographic Details
Main Authors: Nicholas H. Chakiryan, Gregory J. Kimmel, Youngchul Kim, Joseph O. Johnson, Noel Clark, Ali Hajiran, Andrew Chang, Ahmet M. Aydin, Logan Zemp, Esther Katende, Jad Chahoud, Meghan C. Ferrall-Fairbanks, Philippe E. Spiess, Natasha Francis, Michelle Fournier, Jasreman Dhillon, Jong Y. Park, Liang Wang, James J. Mulé, Philipp M. Altrock, Brandon J. Manley
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
metastatic clear cell renal cell carcinoma
cancer associated fibroblasts
Ki-67
spatial analysis
immunohistochemistry
Online Access:https://www.mdpi.com/2072-6694/13/15/3743

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https://www.mdpi.com/2072-6694/13/15/3743

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