Changes in neuronal excitability by activated microglia: Differential Na+ current up-regulation in pyramid-shaped and bipolar neurons by TNF-α and IL-18

Changes in neuronal excitability by activated microglia: Differential Na+ current up-regulation in pyramid-shaped and bipolar neurons by TNF-α and IL-18

Microglia are activated during pathological events in the brain and are capable of releasing various types of inflammatory cytokines. Here we demonstrate that the addition of 5% microglia activated by 1 µg/ml lipopolysaccharides (LPS) to hippocampal cultures up-regulates Na+ current densities (INavD...

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Bibliographic Details
Main Authors: Lars eKlapal, Birte Anna Igelhorst, Irmgard Dorothea Dietzel
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Neurology
Subjects:
Interleukin-18
Microglia
lipopolysaccharide
glial cells
Pyramidal neurons
hippocampal neurons
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00044/full

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