Changes in neuronal excitability by activated microglia: Differential Na+ current up-regulation in pyramid-shaped and bipolar neurons by TNF-α and IL-18
Microglia are activated during pathological events in the brain and are capable of releasing various types of inflammatory cytokines. Here we demonstrate that the addition of 5% microglia activated by 1 µg/ml lipopolysaccharides (LPS) to hippocampal cultures up-regulates Na+ current densities (INavD...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-03-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00044/full |