Synthesis of Gemcitabine-13C, 15N2 and Gemcitabine-13C, 15N2 Metabolites
Homemade urea-13C, 15N2 was used to react with 3-methyl acrylonitrile closure to form cytosine-13C, 15N2 (2),which was protected by trimethylsilylation with BSA and condensed with 2-deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate at 120 ℃ to afford blocked gemcitabine-13...
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| Format: | Article |
| Language: | zho |
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Editorial Board of Journal of Isotopes
2014-02-01
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| Series: | Journal of Isotopes |
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| Online Access: | http://www.tws.org.cn/CN/10.7538/tws.2014.27.02.0082 |