Human BM-MSC secretome enhances human granulosa cell proliferation and steroidogenesis and restores ovarian function in primary ovarian insufficiency mouse model

Human BM-MSC secretome enhances human granulosa cell proliferation and steroidogenesis and restores ovarian function in primary ovarian insufficiency mouse model

Abstract Primary ovarian insufficiency (POI) is defined as the loss of ovarian function before 40 years of age. It clinically manifests as amenorrhea, infertility, and signs of estrogen insufficiency. POI is frequently induced by chemotherapy. Gonadotoxic chemotherapy reagents damage granulosa cells...

Full description

Bibliographic Details
Main Authors: Hang-soo Park, Rishi Man Chugh, Abdeljabar El Andaloussi, Elie Hobeika, Sahar Esfandyari, Amro Elsharoud, Mara Ulin, Natalia Garcia, Mahmood Bilal, Ayman Al-Hendy
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-84216-7

Internet

https://doi.org/10.1038/s41598-021-84216-7

Similar Items