Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health

Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health

Here, the authors report an anaerobic metabolic pathway from the dominant gut butyrogen Anaerostipes, showing several strains of this genus to be capable of producing propionate from dietary myo-inositol that associates with reduced fasting-glucose levels in mice.

Bibliographic Details
Main Authors: Thi Phuong Nam Bui, Louise Mannerås-Holm, Robert Puschmann, Hao Wu, Antonio Dario Troise, Bart Nijsse, Sjef Boeren, Fredrik Bäckhed, Dorothea Fiedler, Willem M. deVos
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25081-w
id doaj-0a0896c3fef945c5b35c436a101db9ab
record_format Article
spelling doaj-0a0896c3fef945c5b35c436a101db9ab2021-08-15T11:39:09ZengNature Publishing GroupNature Communications2041-17232021-08-0112111610.1038/s41467-021-25081-wConversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host healthThi Phuong Nam Bui0Louise Mannerås-Holm1Robert Puschmann2Hao Wu3Antonio Dario Troise4Bart Nijsse5Sjef Boeren6Fredrik Bäckhed7Dorothea Fiedler8Willem M. deVos9Laboratory of Microbiology, Wageningen UniversityThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of GothenburgLeibniz-Forschungsinstitut für Molekulare PharmakologieThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of GothenburgProteomics & Mass Spectrometry Laboratory, ISPAAM, National Research CouncilLaboratory of Microbiology, Wageningen UniversityLaboratory of Biochemistry, Wageningen UniversityThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of GothenburgLeibniz-Forschungsinstitut für Molekulare PharmakologieLaboratory of Microbiology, Wageningen UniversityHere, the authors report an anaerobic metabolic pathway from the dominant gut butyrogen Anaerostipes, showing several strains of this genus to be capable of producing propionate from dietary myo-inositol that associates with reduced fasting-glucose levels in mice.https://doi.org/10.1038/s41467-021-25081-w
collection DOAJ
language English
format Article
sources DOAJ
author Thi Phuong Nam Bui
Louise Mannerås-Holm
Robert Puschmann
Hao Wu
Antonio Dario Troise
Bart Nijsse
Sjef Boeren
Fredrik Bäckhed
Dorothea Fiedler
Willem M. deVos
spellingShingle Thi Phuong Nam Bui
Louise Mannerås-Holm
Robert Puschmann
Hao Wu
Antonio Dario Troise
Bart Nijsse
Sjef Boeren
Fredrik Bäckhed
Dorothea Fiedler
Willem M. deVos
Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health
Nature Communications
author_facet Thi Phuong Nam Bui
Louise Mannerås-Holm
Robert Puschmann
Hao Wu
Antonio Dario Troise
Bart Nijsse
Sjef Boeren
Fredrik Bäckhed
Dorothea Fiedler
Willem M. deVos
author_sort Thi Phuong Nam Bui
title Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health
title_short Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health
title_full Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health
title_fullStr Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health
title_full_unstemmed Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health
title_sort conversion of dietary inositol into propionate and acetate by commensal anaerostipes associates with host health
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-08-01
description Here, the authors report an anaerobic metabolic pathway from the dominant gut butyrogen Anaerostipes, showing several strains of this genus to be capable of producing propionate from dietary myo-inositol that associates with reduced fasting-glucose levels in mice.
url https://doi.org/10.1038/s41467-021-25081-w
work_keys_str_mv AT thiphuongnambui conversionofdietaryinositolintopropionateandacetatebycommensalanaerostipesassociateswithhosthealth
AT louisemannerasholm conversionofdietaryinositolintopropionateandacetatebycommensalanaerostipesassociateswithhosthealth
AT robertpuschmann conversionofdietaryinositolintopropionateandacetatebycommensalanaerostipesassociateswithhosthealth
AT haowu conversionofdietaryinositolintopropionateandacetatebycommensalanaerostipesassociateswithhosthealth
AT antoniodariotroise conversionofdietaryinositolintopropionateandacetatebycommensalanaerostipesassociateswithhosthealth
AT bartnijsse conversionofdietaryinositolintopropionateandacetatebycommensalanaerostipesassociateswithhosthealth
AT sjefboeren conversionofdietaryinositolintopropionateandacetatebycommensalanaerostipesassociateswithhosthealth
AT fredrikbackhed conversionofdietaryinositolintopropionateandacetatebycommensalanaerostipesassociateswithhosthealth
AT dorotheafiedler conversionofdietaryinositolintopropionateandacetatebycommensalanaerostipesassociateswithhosthealth
AT willemmdevos conversionofdietaryinositolintopropionateandacetatebycommensalanaerostipesassociateswithhosthealth
_version_ 1721206480446685184

Similar Items