Synthetic chemistry with friendships that unveiled the long-lasting mystery of lipid A

Synthetic chemistry with friendships that unveiled the long-lasting mystery of lipid A

Endotoxin research in recent years at the molecular level has required chemically synthesized lipid A without contamination by other bioactive components. Total synthesis of Escherichia coli -type lipid A was achieved in the 1980s by the challenging spirits of the scientists at Osaka University, Jap...

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Main Author: Kazuyoshi Kawahara
Format: Article
Language:English
Published: SAGE Publishing 2019-04-01
Series:Innate Immunity
Online Access:https://doi.org/10.1177/1753425919835298
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spelling doaj-0a07728da44748ae81152f81bcc7c84c2020-11-25T04:03:18ZengSAGE PublishingInnate Immunity1753-42591753-42672019-04-012510.1177/1753425919835298Synthetic chemistry with friendships that unveiled the long-lasting mystery of lipid AKazuyoshi KawaharaEndotoxin research in recent years at the molecular level has required chemically synthesized lipid A without contamination by other bioactive components. Total synthesis of Escherichia coli -type lipid A was achieved in the 1980s by the challenging spirits of the scientists at Osaka University, Japan. They clarified the role of lipid A in the immunological activities of endotoxin in collaboration with Japanese and German researchers, based on the friendships that existed between them. This article introduces the great contributions made by three generations of professors, Tetsuo Shiba, Shoichi Kusumoto, and Koichi Fukase, at the Laboratory of Natural Product Chemistry at Osaka University, to the study over four decades of endotoxin.https://doi.org/10.1177/1753425919835298
collection DOAJ
language English
format Article
sources DOAJ
author Kazuyoshi Kawahara
spellingShingle Kazuyoshi Kawahara
Synthetic chemistry with friendships that unveiled the long-lasting mystery of lipid A
Innate Immunity
author_facet Kazuyoshi Kawahara
author_sort Kazuyoshi Kawahara
title Synthetic chemistry with friendships that unveiled the long-lasting mystery of lipid A
title_short Synthetic chemistry with friendships that unveiled the long-lasting mystery of lipid A
title_full Synthetic chemistry with friendships that unveiled the long-lasting mystery of lipid A
title_fullStr Synthetic chemistry with friendships that unveiled the long-lasting mystery of lipid A
title_full_unstemmed Synthetic chemistry with friendships that unveiled the long-lasting mystery of lipid A
title_sort synthetic chemistry with friendships that unveiled the long-lasting mystery of lipid a
publisher SAGE Publishing
series Innate Immunity
issn 1753-4259
1753-4267
publishDate 2019-04-01
description Endotoxin research in recent years at the molecular level has required chemically synthesized lipid A without contamination by other bioactive components. Total synthesis of Escherichia coli -type lipid A was achieved in the 1980s by the challenging spirits of the scientists at Osaka University, Japan. They clarified the role of lipid A in the immunological activities of endotoxin in collaboration with Japanese and German researchers, based on the friendships that existed between them. This article introduces the great contributions made by three generations of professors, Tetsuo Shiba, Shoichi Kusumoto, and Koichi Fukase, at the Laboratory of Natural Product Chemistry at Osaka University, to the study over four decades of endotoxin.
url https://doi.org/10.1177/1753425919835298
work_keys_str_mv AT kazuyoshikawahara syntheticchemistrywithfriendshipsthatunveiledthelonglastingmysteryoflipida
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