Incorporating Phylogenetic Information in Microbiome Differential Abundance Studies Has No Effect on Detection Power and FDR Control

Incorporating Phylogenetic Information in Microbiome Differential Abundance Studies Has No Effect on Detection Power and FDR Control

We consider the problem of incorporating evolutionary information (e.g., taxonomic or phylogenic trees) in the context of metagenomics differential analysis. Recent results published in the literature propose different ways to leverage the tree structure to increase the detection rate of differentia...

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Bibliographic Details
Main Authors: Antoine Bichat, Jonathan Plassais, Christophe Ambroise, Mahendra Mariadassou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Microbiology
Subjects:
microbiome
metagenomics
multiple testing
false discovery rate
correlation
phylogeny
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00649/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00649/full

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