Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway.

Glioma cell death induced by irradiation or alkylating agent chemotherapy is independent of the intrinsic ceramide pathway.

Resistance to genotoxic therapy is a characteristic feature of glioma cells. Acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to ceramide and glucosylceramide synthase (GCS) catalyzes ceramide metabolism. Increased ceramide levels have been suggested to enhance chemotherapy-induced death of canc...

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Bibliographic Details
Main Authors: Dorothee Gramatzki, Caroline Herrmann, Caroline Happold, Katrin Anne Becker, Erich Gulbins, Michael Weller, Ghazaleh Tabatabai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3646759?pdf=render

Internet

http://europepmc.org/articles/PMC3646759?pdf=render

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