Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease

Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease

Abstract Background The spread of tau pathology in Alzheimer’s disease (AD) is mediated by cell-to-cell transmission of pathological tau seeds released from neurons that, upon internalization by recipient neurons, template the misfolding of naïve cellular tau, thereby propagating fibrillization. We...

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Bibliographic Details
Main Authors: Garrett S. Gibbons, Soo-Jung Kim, Qihui Wu, Dawn M. Riddle, Susan N. Leight, Lakshmi Changolkar, Hong Xu, Emily S. Meymand, Mia O’Reilly, Bin Zhang, Kurt R. Brunden, John Q. Trojanowski, Virginia M. Y. Lee
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Molecular Neurodegeneration
Subjects:
Tau
Immunotherapy
Alzheimer’s disease
Tauopathies
Monoclonal antibodies
Online Access:http://link.springer.com/article/10.1186/s13024-020-00404-5

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http://link.springer.com/article/10.1186/s13024-020-00404-5

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