Progestin and AdipoQ Receptor 3 Upregulates Fibronectin and Intercellular Adhesion Molecule-1 in Glomerular Mesangial Cells via Activating NF-κB Signaling Pathway Under High Glucose Conditions

Progestin and AdipoQ Receptor 3 Upregulates Fibronectin and Intercellular Adhesion Molecule-1 in Glomerular Mesangial Cells via Activating NF-κB Signaling Pathway Under High Glucose Conditions

BackgroundProgestin and adipoQ receptor 3 (PAQR3), is a Golgi-anchored membrane protein containing seven transmembrane helices. It has been demonstrated that PAQR3 mediates insulin resistance, glucose and lipid metabolism, and inflammation. In addition, kidney inflammatory fibrosis is an important p...

Full description

Bibliographic Details
Main Authors: Yezi Zou, Zhiquan Chen, Jie Li, Wenyan Gong, Lei Zhang, Futian Xu, Lihao Chen, Peiqing Liu, Heqing Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Endocrinology
Subjects:
progestin and adipoQ receptor 3
diabetic nephropathy
inflammatory fibrosis
NF-κB
inhibitor of nuclear factor κB kinase β
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00275/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2018.00275/full

Similar Items